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Pathways Recommended: PROTAC
Results for "

PROTAC SGK3 degrader-1

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125878
    PROTAC SGK3 degrader-1
    2 Publications Verification

    SGK3-PROTAC1

    		 PROTACs SGK Cancer
    PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on von Hippel-Lindau ligand. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate) .
    <em>PROTAC</em> <em>SGK3</em> <em>degrader-1</em>
  • HY-130620
    PEG3-C4-OBn

    		PROTAC Linkers Cancer
    PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. PEG3-C4-OBn can be used in the synthesis of the PROTAC SGK3 degrader-1 (HY-125878). PROTAC SGK3 degrader-1 is a potent SKG3 degrader based on PROTAC .
    PEG3-C4-OBn
  • HY-130621
    OTs-C6-OBn

    		PROTAC Linkers Cancer
    OTs-C6-OBn is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878) .
    OTs-C6-OBn
  • HY-130619
    Boc-C1-PEG3-C4-OBn

    		PROTAC Linkers Cancer
    Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
    Boc-C1-PEG3-C4-OBn
  • HY-130770
    Ald-CH2-PEG3-CH2-Boc

    		PROTAC Linkers Cancer
    Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader .
    Ald-CH2-PEG3-CH2-Boc

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